Table 3 Effect of Bm-ipgm gene silencing on adult male and female B. malayi
| Â | Motility score (female worms) | % Inhibition in MTT reduction | Motility score *(male worms) | % Inhibition in MTT reduction | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
Time( hr) | Control | Negative siRNA | Gene specific siRNA | Negative siRNA | Gene specific siRNA | Control | Negative siRNA | Gene specific siRNA | Negative siRNA | Gene specific siRNA |
12 | 5 | 5 | 4 | 2.25 ± 3.3 | 29.9 ± 5.4 | 5 | 5 | 4 | 2.5 ± 1.3 | 26.8 ± 4.5 |
24 | 5 | 5 | 3 | 4.5 ± 1.2 | 40.2 ± 6.2 | 5 | 5 | 3 | 4.5 ± 1.3 | 38.8 ± 6.5 |
36 | 4 | 5 | 3 | 5.0 ± 2.3 | 55.4 ± 6.3 | 4 | 4 | 2 | 4.5 ± 2.6 | 64.4 ± 5.4 |
48 | 4 | 4 | 2 | 6.2 ± 2.8 | 74.4 ± 3.4 | 4 | 4 | 1 | 6 ± 1.8 | 80.2 ± 6.8 |
108 | 4 | 4 | 2 | 6.26 ± 2.3 | 75.9 ± 4.7 | 4 | 4 | 1 | 5.25 ± 2.6 | 89.4 ± 5.3 |