Table 2 Characteristics of the included studies
Study | Study design | Country | Intervention | Target population | Integrated/Non-Integrated |
|---|---|---|---|---|---|
Adam 1995 [13] | RCT | Kenya | Three doses of 400 mg ALB vs. identical placebo on three consecutive school days | Children aged 5–10 years infected with hookworms or ascariasis | School-based |
Ageel 1997 [33] | Pre/post | Saudi Arabia | One oral dose of PZQ (40 mg/kg) + snail/vector control + health education + community participation | General population infected with schistosomiasis | PHC |
Albonico 2002 [14] | RCT | Tanzania | MBZ 500 mg vs. pyrantel-oxantel (10 mg/kg) vs. placebo | Children aged 6–9 years | School-based |
Bausch 1995 [35] | Quasi | Cameroon | Health education + PZQ | Children aged 5–15 years with schistosomiasis | PHC + school-based |
Beasely 1999 [25] | RCT | Tanzania | Single dose of 400 mg ALB + PPZQ (40 mg/kg) vs. placebo | Infected children aged 7–12 years | Non-integrated |
Bhargawa 2003 [15] | RCT | Tanzania | ALB 400 mg + PZQ single 40 mg/kg vs. placebo | Infected children aged 9–15 years | School-based |
Christian 2009 [36] | RCT | Nepal | ALB 40 mg in 2nd + 3rd trimester | Pregnant women | Integrated with routine ANC |
Dossa 2001 [26] | RCT | Benin | Iron (Fe) (60 mg/day) + ALB (200 mg for 3 days) vs. FE + placebo vs. ALB + placebo vs. placebo 10 months F/V | Children aged 3–5 years | Non-integrated |
Engels 1993 [11] | Pre/post | Burundi | Single dose PZQ (40 mg/kg), 50–150 mg levamisole or 500 mg MBL or PZQ (20 mg/kg) + snail vector control + education | General population | PHC |
Gryseels 1991 [23] | Pre/post | Burundi | PZQ (40Â mg/kg) | General population | Non-integrated |
Gundersen 1990 [34] | Pre/post | Ethiopia | Vector snail control + 20 mg oxamniquine followed by 40 mg the next day | General population | PHC |
Guyatt 2001 [16] | Pre/post | Tanzania | Single dose 400 mg ALB + PZQ 40 mg/kg | School children aged 8–14 years | School-based |
Halwindi 2011 [27] | RCT | Zambia | Facility vs. community detected and treatment + training + education + MBZ | Children aged 12–months (preventive) | Non-integrated |
Haque 2010 [28] | RCT | Bangladesh | 400 mg ALB + B-carotene (2 doses) vs. ALB + placebo vs. B-carotene + placebo vs. placebo + placebo | Infected children aged 24–60 months | Non-integrated |
Hathirat 1992 [24] | RCT | Thailand | Fe 50 mg FeSo 4 daily for 2 weeks then 100 mg for 14wks vs. anthelminthic | Children aged 9–11 years | School-based |
Kosinski 2012 [31] | Pre/post | Ghana | Water recreation area + PZQ | Children | Non-integrated |
Koukounari 2006 [17] | Pre/post | Uganda | PZQ | Children aged 7–14 years | School-based |
Koukounari 2007 [18] | Pre/post | Burkina Faso | PZQ 40 mg/kg + ALB 400 mg | Children aged 6–14 years | School-based |
Larocque 2006 [37] | RCT | Peru | MBZ 500 mg single dose + 60 mg FE daily vs. placebo + FE | Pregant women aged 18–44 years in the 2nd trimester | Integrated with routine ANC |
Ndibazza 2010 [38] | RCT | Uganda | ALB (400 mg) vs. PZQ 40 mg/kg vs. ALB + PZQ vs. placebo | Pregnant women | Integrated with routine ANC |
Nsowah-Nuamah 2001 [12] | Pre/post | Ghana | PZQ 40 mg/kg + passive edu vs. PZQ + no education vs. PZQ + active edu vs. community mobilization | Those aged 5 years and above | Non-integrated |
Olds 1999 [29] | RCT | China and Philippines | ALB + PZQ vs. PZQ + ALB placebo vs. ALB + PZQ placebo vs. placebo + placebo | Infected school aged children (4–18 years) | Non-integrated |
Palupi 1997 [30] | RCT | Indonesia | FE + ALB 400 mg once a week vs. FE once a week + placebo vs. placebo alone | Children aged 2–5 years | Non-integrated |
Phuc 2009 [40] | Pre/post | Vietnam | IEC materials + staff training + Ferrous Sulphate/ folic acid (200 mg) + ALB (400 mg) | Women of reproductive age (16–45 years) | Non-integrated |
Rohner 2010 [19] | RCT | Cote d’Ivoire | Iron fortified biscuits (20 mg fe/day) + IPT-SP (500 mg sulphadoxine + 25 mg pyrimethamine) + anthelminthic (400 mg-single) + PZQ (single – 40 mg/kg) in different combinations | School children aged 6–14 years | School-based |
Savioli 1989 [9] | Pre/post | Tanzania | PZQ | Children | School-based |
Sungthong 2002 [20] | RCT | Thailand | Deworming (400 mg ALB single) + daily or weekly iron | Children aged 6–13 years | School-based |
Sinoun 2007 [10] | Pre/post | Cambodia | Universal chemotherapy with PZQ (40Â mg/kg) | General population | Non-integrated |
Taylor 2001 [21] | RCT | South Africa | ALB (400 mg) + PZQ (40 mg/kg) + FE fumigate 200 mg weekly vs. ALB (400 mg) + PZQ (40 mg/kg) + placebo weekly vs. ALB (400 mg) daily + PZQ (40 mg/kg) + FE 200 mg weekly vs. ALB (400 mg) + PZQ (40 mg/kg) + placebo weekly vs. placebos + FE 200 mg weekly vs. placebos | Children aged 6–15 years | School-based |
Torlesse 2001 [39] | RCT | Sierra Leone | FE + ALB vs. FE alone vs. ALB alone vs. placebo | Pregnant women (10–14 weeks) | Integrated with routine ANC |
Wang 2009 [32] | Quasi | China | Health education + vector control + removing cattle + latrines + PZQ | General population | Non-integrated |
Zhang 2007 [22] | Pre/post | Uganda | PZQ (40 mg/kg) + ALB(400 mg) + education | School children and adults | Non-integrated |