Immuno-haematologic and virologic responses and predictors of virologic failure in HIV-1 infected adults on first-line antiretroviral therapy in Cameroon

Table 3 Mean CD4 + Tcell count, viral load and haematologic parameters of study participants grouped by ART duration, regimen type and co-infection status

	CD4+ T-cell count		Log₁₀viral load		Mean haematologic parameters ± SD
Variables Category	N	Mean ± SD [cell/μL]	N	Mean ± SD [copies/mL]	N	Hgb [g/dL]	RBC [x10⁶/mm³]	WBC [x10³/mm³]	Platelet [x10⁵/mm³]
ART duration (Months)
< 12	106	168.9 ± 143.8	118	3.60 ± 1.27	135	11.54 ± 2.09^ℓ	3.58 ± 0.61	4.10 ± 1.49	2.50 ± 0.95
12 – 36	255	266.3 ± 214.1^§	153	3.07 ± 1.38	294	11.97 ± 1.90^₸	3.63 ± 0.59	4.33 ± 1.61	2.29 ± 0.77
> 36	130	318.7 ± 220.5^*	60	2.93 ± 1.05	192	12.56 ± 2.06	3.78 ± 0.66^∞	4.69 ± 1.75^δ	2.36 ± 0.77
p-value		< 0.001		0.001		< 0.001	0.008	0.004	0.054
Regimen type
EFV-based	163	241.0 ± 186.4	84	3.20 ± 1.37	179	11.91 ± 1.96	3.59 ± 0.59	4.28 ± 1.65	2.48 ± 0.97
NVP-based	297	268.9 ± 219.8	243	3.26 ± 1.30	436	12.12 ± 2.06	3.69 ± 0.63	4.44 ± 1.65	2.31 ± 0.75
p-value		0.171		0.683		0.241	0.087	0.287	0.024
Co-Infection status
HIV only	398	274.3 ± 216.6	255	3.18 ± 1.35	574	12.14 ± 2.02	3.71 ± 0.62	4.44 ± 1.67	2.36 ± 0.76
HIV/TB	66	171.1 ± 112.1	42	3.50 ± 1.34	63	10.89 ± 1.86	3.09 ± 0.42	3.89 ± 1.06	2.20 ± 1.22
p-value		< 0.001		0.166		< 0.001	< 0.001	0.011	0.154

EFV-Efavirenz, NVP-Nevirapine, ^§ higher than < 12 months [P = 0.03], ^* higher than < 12 months and 12–36 months [P < 0.001], ^ℓ lower than 12–36 and > 36 months [P < 0.02], ^⍑ lower than > 36 months [P = 0.02], ^∞ higher than < 12 months [P = 0.012], ^δ higher 12 months [P = 0.004].

ISSN: 2049-9957