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Table 5 Behavioural and clinical factors associated with virologic failure and risk estimates

From: Immuno-haematologic and virologic responses and predictors of virologic failure in HIV-1 infected adults on first-line antiretroviral therapy in Cameroon

Factors Behavioural

Virologic responses: prevalence, n (%)

Risk estimates (95% CI)

 

N

VF

AS

p-value

Crude odd ratio

Adjusted odd ratio

p-value

Alcohol:

       

 Yes

313

65 (20.8)

248 (79.2)

0.927

0.98 (0.66-1.46)

  

 No

280

59 (21.1)

221 (78.9)

 

1

  

Smoking:

       

 Yes

55

15 (27.3)

40 (72.7)

0.223

1.48 (0.79-2.77)

  

 No

538

109 (20.3)

429 (79.7)

 

1

  

Clinical history

       

Duration of ART

       

 (months): ≤ 12

108

48 (44.4)

60 (55.6)

< 0.001

4.24 (2.49-7.23)

1.11 (0.40-3.16)

0.851

 12-36

361

76 (21.1)

285 (78.9)

 

1.41 (0.90-2.22)

1.57 (0.73-3.36)

0.251

 > 36

208

33 (15.9)

175 (84.1)

 

1

1

 

Regimen type:

       

 EFV-based

177

35 (19.8)

142 (80.2)

0.232

0.77 (0.51-1.18)

  

 NVP-based

492

119 (24.2)

373 (75.8)

 

1

  

Co-infection status:

       

 HIV/TB co-infected

51

22 (45.1)

28 (54.9)

< 0.001

3.24 (1.80-5.84)

0.20 (0.04-0.70)

0.014

 HIV only

589

119 (20.2)

470 (79.8)

 

1

1

 

CD4+T-cell (cells/μL):

       

 < 200

154

46 (29.9)

108 (70.1)

0.002

2.49 (1.0-6.31)

0.68 (0.23-2.05)

0.497

 200 - 499

165

24 (14.5)

141 (85.5)

 

1.69 (0.63-4.49)

1.22 (0.40-3.75)

0.724

 ≥ 500

41

06 (14.6)

35 (85.4)

 

1

1

 

Anaemic status (g/dL):

       

 Anaemic

114

34 (29.8)

80 (70.2)

< 0.001

2.48 (1.52-4.07)

2.30 (1.10-4.83)

0.028

 Non-anaemic

376

55 (14.6)

321 (85.4)

 

1

1

 
  1. VF: Virologic failure (viral load > 400 RNA copies/mL after ≥ 6 months of ART), AS: Adequate suppression (≥ 400 RNA copies/mL after ≥ 6 months of ART), Anaemia: Hgb < 11 g/dl, CI - confidence interval.
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Infectious Diseases of Poverty

ISSN: 2049-9957

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