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Table 4 Sensitivity of P. falciparum to pyronaridine and artesunate

From: Surveillance of antimalarial drug resistance in China in the 1980s–1990s

Drug

Province

In vitro test

In vivo test

Year

No. of cases examined

Inhibition concentration(pmoll)*

Year

No. of cases examined

Defervescence time(h)

Parasite clearance time(h)

Pyronaridine

Hainan

1986

20

0.08

1986

42

32.9 ± 12.4

43.3 ± 23.3

1997

37

1.36

1996

13

40.2 ± 15.7

62.5 ± 28.7

Yunnan

1988

25

0.14

    

Artesunate

Hainan

1986

18

0.028

    

2002

32

0.135

    

Yunnan

1988

24

0.038

    

2002

22

0.054

    
  1. *The mean drug concentration for complete inhibition of schizont maturation.