From: Surveillance of antimalarial drug resistance in China in the 1980s–1990s
Drug | Province | In vitro test | In vivo test | |||||
---|---|---|---|---|---|---|---|---|
Year | No. of cases examined | Inhibition concentration(pmol/μl)* | Year | No. of cases examined | Defervescence time(h) | Parasite clearance time(h) | ||
Pyronaridine | Hainan | 1986 | 20 | 0.08 | 1986 | 42 | 32.9 ± 12.4 | 43.3 ± 23.3 |
1997 | 37 | 1.36 | 1996 | 13 | 40.2 ± 15.7 | 62.5 ± 28.7 | ||
Yunnan | 1988 | 25 | 0.14 | |||||
Artesunate | Hainan | 1986 | 18 | 0.028 | ||||
2002 | 32 | 0.135 | ||||||
Yunnan | 1988 | 24 | 0.038 | |||||
2002 | 22 | 0.054 |