Fig. 5From: Prediction of the next highly pathogenic avian influenza pandemic that can cause illness in humansThe analogy between lock and key and AIV pathogenicity and transmissibility. The human α-2,6-linked SA is like a lock and an AIV is like a key. The HA-160A/186V/226L (or other) and PB2-627K mutations are like the two teeth of the key. The HA 5′-UTR energy is like the handle of the key, the size of which determines the key’s twisting force. The depth of the red color shows the virulence level. Question marks denote that the original HA 5′-UTR sequences were not availableBack to article page