Table 6 Therapeutic outcomes based on age group in children treated with artemether-lumefantrine
Parameter | ≤2 years (n = 130) | <5 years (n = 418) | ||||
|---|---|---|---|---|---|---|
<1 year (n = 46) | ≥1 year (n = 84) | P value | ≤2 years (n = 130) | ≥2– < 5 years (n = 288) | P value | |
Haematocrit (%) | ||||||
 Mean | 28.9 | 28.9 | 0.96 | 28.9 | 29.9 | 0.05 |
 95 % CI | 27.4–30.3 | 28–29.8 | 28.1–29.7 | 29.3–30.5 | ||
 No <30 % | 19 | 40 | 0.61 | 59 | 129 | 0.99 |
Parasitaemia (μL−1) | ||||||
 Geometric mean | 11,981 | 17,207 | 0.16 | 15,138 | 23,001 | 0.003 |
 Range | 1,000–304,500 | 1108–288,461 |  | 1,000–305,500 | 1,030–2,124,000 |  |
 No. >100,000 μL−1 | 1 | 6 | 0.43 | 7 | 50 | 0.002 |
 No. >250,000 μL−1 | 1 | 1 | 1.0 | 2 | 8 | 0.73 |
 ACPR on day 28 (%) | 45/46 (98) | 77/81 (95) | 0.65 | 122/127 (96) | 265/279 (95) | 0.82 |
 Parasite prevalence on day 1 | 18 (39) | 60 | 0.04 | 68 (52) | 154 (53) | 0.91 |
PRRD1 | ||||||
 Geometric mean | 9.1 × 102 | 4.0 × 102 | 0.31 | 5.4 × 102 | 5.6 × 102 | 1.0 |
 Range | 1.7 × 100–8.7 × 104 | 4.1 × 10−1–2.9 × 105 |  | 4.1 × 10−1–2.9 × 105 | 9.5 × 10−1–2.1 × 106 |  |
PRRD2 | ||||||
 Geometric mean | 1.1 × 104 | 1.2 × 104 | 0.51 | 1.1 × 104 | 1.8 × 104 | 0.004 |
 Range | 3.2 × 101–3.0 × 105 | 2.6 × 101–2.9 × 105 |  | 2.6 × 101–3.0 × 105 | 1.7 × 101–2.1 × 106 |  |
 Parasite positivity rate on day 3 | 0 | 1 | - | 1 | 1 | 0.53 |
Fever clearance time (day) | ||||||
 Mean | 1.2 | 1.3 | 0.64 | 1.3 | 1.2 | 0.4 |
 95 % CI | 1.1–1.4 | 1–1.6 | 1.1–1.5 | 1.1–1.3 | ||
Parasite clearance time (day) | ||||||
 Mean | 1.4 | 1.7 | 0.01 | 1.6 | 1.6 | 0.92 |
 95 % CI | 1.3–1.6 | 1.6–1.8 | 1.5–1.7 | 1.5–1.7 | ||
Anaemia recovery time (day) | ||||||
 Mean | 15.3 | 12.5 | 0.29 | 13.2 | 11 | 0.12 |
 95 % CI | 10.6–20.1 | 9.7–15.3 | 10.9–15.6 | 9.4–12.6 | ||