Hepatitis E infection among Ghanaians: a systematic review

Table 1 Studies on hepatitis E in Ghana

Serological Studies reporting markers of HEV infection
Study No.	Reference	Publication year	Sampling year	Design	Region	Sample size	Setting	Participants	Age of participants	Anti -HEV (%)			Quality grade
										Total Ig	IgG	IgM
1	Martinson et al. [17]	1999	1993	Cross sectional	Ashanti	803	Rural	Children	6-18	4.4	n.s	n.s	High
2	Adjei et al. [9]	2009	2008	Cross sectional	Greater Accra	157	Urban	Pregnant women	13-42	28.66	10.19	18.47	High
3	Adjei et al. [18]	2009	2008	Cross sectional	Greater Accra	105	Urban	Pig handlers	12–65	38.1	0.0	38.1	High
4	Adjei et al. [19]	2010	2008	Cross sectional	Greater Accra	353	Urban	Pig handlers	15-70	38.48	19.26	15.58	High
5	Tettey [20]	2011	2008	Cross sectional	Greater Accra	471	Urban	Blood donors	18-60 (m) 19–42 (f)	71.55	25.6	45.9	Medium
6	Meldal et al. [21]	2012	n.s	Cross sectional	Ashanti	239	Urban	Blood donors	n.s	10.5	4.6	5.9	High
7	Feldt et al. [22]	2013	2008-10	Cross sectional	Ashanti	402	Urban	Adult HIV patients	40 (±9.6)	46.02	45.3	0.7	High
8	Bonney et al. [23]	2013	2009-13	Hospital-based surveillance study	Ashanti, Brong-Ahafo, Northern, Upper West, Upper East	258	Mixed	Patients with VHF symptoms	23.5^a	9.7	5.8	3.9	High
9	Ofosu-Appiah et al. [24]	2016	2010-11	Cross-sectional	Greater Accra	103	Urban	Patients with suspected hepatitis	33.0 ± 14.5	5.8	n.s	n.s	Medium
Studies reporting Case Fatality Rate
	Reference	Publication year	Sampling year	Design	Region	Sample size	Setting	Participants	Age of participants	Case fatality-rate			Quality grade
10	Bonney et al. [25]	2012	2010	Case series	Greater Accra	3	Urban	Pregnant women	31, 31, 17	66.7%			High

VHF viral haemorrhagic fever; n.s not specified; m male; f female; IgG Immunoglobulin G; IgM immunoglobulin M; HEV RNA hepatitis E virus RNA
^a median

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