From: Controlling schistosomiasis with praziquantel: How much longer without a viable alternative?
Chemical compound/drug | Dose | Worm burden reduction (adult) | Worm burden reduction (juvenile) | Reference |
---|---|---|---|---|
Artemether | 300 mg/kg/day for 2 days | 85.4–98.3% | 70% | [52] |
Artesunate | 150 or 300 mg/kg/day for 7 days | 34–49% | 67–77% | [53] |
Bisquinoline cyclen derivative | 400Â mg/kg single dose | 12.3% | Not done | [74] |
Bisquinoline cyclen derivative (Fe++ complex) | 400Â mg/kg single dose | 88.4% | Not done | [74] |
Bisquinoline cyclen derivative (Mn++ complex) | 400Â mg/kg single dose | 74.5% | Not done | [74] |
Chlorambucil | 2.5Â mg/kg/day for 5Â days | 22.7% | 75.8% | [77] |
Clofazimine | 400Â mg/kg single dose | 82.7% | Not done | [84] |
2,3-dianilinoquinoxaline MMV007224 | 400Â mg/kg single dose | 40.8% | Not done | [71] |
N,N’-Diarylurea MMV665852 | 400 mg/kg single dose | 52.5% | Not done | [71] |
N,N’-Diarylurea MMV665852 analogs | 400 mg/kg single dose | 9.3–36% | Not done | [72] |
Doramectin | 10Â mg/kg single dose | 60.1% | Not done | [84] |
Mefloquine | 400Â mg/kg single dose (adult), 100Â mg/kg (juvenile) | 77.3% | 94.2% | [65] |
Mefloquine derivatives | 100 mg/kg single dose | 0-87% | Not done | [69] |
Miltefosin | 20Â mg/kg daily for 5Â days | 95.4% | 75.5% | [75] |
OZ78 | 200Â mg/kg single dose (juvenile), 400Â mg/kg single dose (adult) | 0% | 82% | [57] |
OZ209 | 200Â mg/kg single dose (juvenile), 400Â mg/kg single dose (adult) | 16% | 85% | [57] |
OZ288 | 200Â mg/kg single dose (juvenile), 400Â mg/kg single dose (adult) | 52.2% | 95.4% | [57] |
OZ418 | 200Â mg/kg single dose (juvenile), 400Â mg/kg single dose (adult) | 80% | 100% | [59] |
Perhexiline maleate | 23, 70 and 400Â mg/kg single dose | Not given | Not given | [83] |
Piperaquine/OZ277 (Synriam) | 40Â mg/kg arterolane (OZ277) and 200Â mg/kg piperaquine | 88.7% | 85.4% | [61] |
Ferroquine | 200Â mg/kg and 800Â mg/kg single dose | 19.4% and 35.6% | Not done | [73] |