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Table 1 Activity observed with drug discovery candidates in the S. mansoni-mouse model

From: Controlling schistosomiasis with praziquantel: How much longer without a viable alternative?

Chemical compound/drug

Dose

Worm burden reduction (adult)

Worm burden reduction (juvenile)

Reference

Artemether

300 mg/kg/day for 2 days

85.4–98.3%

70%

[52]

Artesunate

150 or 300 mg/kg/day for 7 days

34–49%

67–77%

[53]

Bisquinoline cyclen derivative

400 mg/kg single dose

12.3%

Not done

[74]

Bisquinoline cyclen derivative (Fe++ complex)

400 mg/kg single dose

88.4%

Not done

[74]

Bisquinoline cyclen derivative (Mn++ complex)

400 mg/kg single dose

74.5%

Not done

[74]

Chlorambucil

2.5 mg/kg/day for 5 days

22.7%

75.8%

[77]

Clofazimine

400 mg/kg single dose

82.7%

Not done

[84]

2,3-dianilinoquinoxaline MMV007224

400 mg/kg single dose

40.8%

Not done

[71]

N,N’-Diarylurea MMV665852

400 mg/kg single dose

52.5%

Not done

[71]

N,N’-Diarylurea MMV665852 analogs

400 mg/kg single dose

9.3–36%

Not done

[72]

Doramectin

10 mg/kg single dose

60.1%

Not done

[84]

Mefloquine

400 mg/kg single dose (adult), 100 mg/kg (juvenile)

77.3%

94.2%

[65]

Mefloquine derivatives

100 mg/kg single dose

0-87%

Not done

[69]

Miltefosin

20 mg/kg daily for 5 days

95.4%

75.5%

[75]

OZ78

200 mg/kg single dose (juvenile), 400 mg/kg single dose (adult)

0%

82%

[57]

OZ209

200 mg/kg single dose (juvenile), 400 mg/kg single dose (adult)

16%

85%

[57]

OZ288

200 mg/kg single dose (juvenile), 400 mg/kg single dose (adult)

52.2%

95.4%

[57]

OZ418

200 mg/kg single dose (juvenile), 400 mg/kg single dose (adult)

80%

100%

[59]

Perhexiline maleate

23, 70 and 400 mg/kg single dose

Not given

Not given

[83]

Piperaquine/OZ277 (Synriam)

40 mg/kg arterolane (OZ277) and 200 mg/kg piperaquine

88.7%

85.4%

[61]

Ferroquine

200 mg/kg and 800 mg/kg single dose

19.4% and 35.6%

Not done

[73]