Comparison of novel and standard diagnostic tools for the detection of Schistosoma mekongi infection in Lao People’s Democratic Republic and Cambodia

Table 5 Diagnostic characteristics of the various tests to diagnose S. mekongi infection using a combined reference^a

Method	ELISA^b	Kato-Katz	POC-CCA	CAA	CAA	CAA
Target	Antibodies	Parasite eggs	Circulating antigens
Sample	Serum	Faeces	Urine	Urine	Serum	Serum + urine
	(%)	(%)	(%)	(%)	(%)	(%)
Sensitivity	52.9	13.8	24.1	83.9	70.1	93.7
Specificity	81.3	100	81.8	100	100	100
PPV*	70.8	100	53.2	100	100	100
NPV**	66.8	57.5	55.7	87.9	79.6	94.9

*Positive predictive value; **Negative predictive value; ^aInfection-positive by either egg- or CAA-positivity (serum and urine combined, assuming 100% specificity of the CAA result). ^bFor the ELISA, either AWE and/or SEA positive was considered positive

ISSN: 2049-9957