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Table 4 Pharmacokinetic parameters in plasma after a single 100 mg/kg dose of the new PZQ slow-release formulation

From: Slow-release praziquantel for dogs: presentation of a new formulation for echinococcosis control

Formulation

Dose(mg/kg)

Tmax/h

Cmax/μg·l−1

T1/2/h

MRT/h

AUC/μg·l−1·h

R-PZQ

50

2 ± 0

321 ± 26

2025 ± 1458

1180 ± 374

92,240 ± 14,546

S-PZQ

50

2 ± 0

719 ± 263*

1003 ± 406

601 ± 106*

165,348 ± 31359**

  1. Average of results based on plasm from beagle dogs (N = 6); data are expressed as mean ± SD; the AUC values zero to time “t”; * P < 0.05; ** P < 0.01 vs. R-PZQ (“*” refers to significant difference when S-PZQ was compared with R-PZQ using the two-tailed t-test)
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Infectious Diseases of Poverty

ISSN: 2049-9957

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