Pharmacological and immunological effects of praziquantel against Schistosoma japonicum: a scoping review of experimental studies

Table 3 Pharmacokinetics and therapeutic efficacy of praziquantel in S. japonicum-infected mice and rabbits after oral (PO), rectal (PR) and intramuscular (IM) administration

Animal	Time after infection (week)	Dose (mg/kg)	Route	Tmax (h)	Cmax (μg/ml)	T_1/2 (h)	AUC_0-∞ (μg/ml × h)	Worm burden reduction (%)	Reference
Mice	4	300	PO	0.27	20.2	0.8	30.6	46.2
	5	300	PO	0.59	29.1	0.5	49.8	65.3
	5	150	IM	0.58	31.3	0.7	60.3	52.2
	6	300	PO	0.50	34.0	0.6	55.2	93.8
Rabbits	4	40	PO	0.3	0.05	0.9	0.08	60.8
	8	40	PO	0.34	0.64	3.04	3.03	94.9
	12	40	PO	0.43	0.50	1.08	1.01	89.0
	4	20	IM	1.49	1.92	1.27	8.17	70.9
	8	20	IM	1.32	1.65	1.86	7.59	88.0
	12	20	IM	1.11	1.45	1.35	5.25	95.2	[83]
	8	40	PO	0.5–0.6	0.1–0.3	1.3–1.6	0.1–0.9	72.5
	8	40	PR	0.4	0.7–0.8	0.5–0.6	0.9–1.0	90.1
	8	20	IM	0.5–1.2	0.8–2.3	1.2–1.6	2.6–5.9	92.2	[84]

ISSN: 2049-9957