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Table 3 E. granulosus worm burdens at day 45 post-infection with in dogs (local Xinjiang breed) vaccinated with rEgM9 and rEgM123 proteins coupled with ISCOMs

From: Dog vaccination with EgM proteins against Echinococcus granulosus

Group (protein)

Dog No.

Number of worms

  

Total

≤3 seg

%

≥4 seg

%

Gravid Seg

%

GST control

802

24 618

24 618

100.0

0

0.0

0

0.0

810

15 273

15 273

100.0

0

0.0

0

0.0

811

2784

2784

100.0

0

0.0

0

0.0

1313

41 288

22 857

55.4

18 431

44.6

0

0.0

1314

11 547

7362

63.8

4185

36.2

0

0.0

Average

19 102

14 579

76.3

11 308

59.2

0

0.0

SD

14 669

9500

10 073

0

Median

15 273

15 273

0

0

IQR

(7166, 32 953)

(5073,23 738)

(0, 11 308)

(0,0)

EgM9

804

41 573

6214

14.9

35 359

85.1

0

0.0

808

59

8

13.6

51

86.4

0

0.0

848

13 262

13 262

100.0

0

0.0

0

0.0

849

2933

2933

100.0

0

0.0

0

0.0

Average

14 457

5604

38.8

8853

61.2

0

0.0

SD

18 946

5700

24 967

0

Median

8098

4574

26

0

IQR

(778, 34 495)

(739, 11 500)

(0, 26 532)

(0,0)

Redu%a

47.0

59.3

-100

0

P valueb

0.624

0.142

0.788

1.000

EgM123

803

5729

5729

100.0

0

0.0

0

0.0

806

12 058

12 058

100.0

0

0.0

0

0.0

812

28

28

100.0

0

0.0

0

0.0

847

1653

301

18.2

1352

81.8

0

0.0

850

23

23

100.0

0

0.0

0

0.0

Average

3898

3628

93.1

270

34.7

0

0.0

SD

5123

5303

604

0

Median IQR

1653 (26, 8894)

301 (26, 8894)

0 (0,676)

0 (0,0)

Redu%a

89.2

98.0

0

0

IQR

(26,8894)

(26, 8894)

 

(0, 676)

 

(0, 0)

 

P valueb

0.047

0.047

0.368

1.000

  1. aCompared to those in the GST group. Redu, reduction = (worm burden median in GST-worm burden median in the experiment group)/worm burden median in GST group × 100%. bThe Mann-Whitney U test was used to compare the worm burden median. P value less than 0.05 means that reduction is significant between GST and experimental groups using median analysis. The meaning of a, bis the same in the following tables