Table 3 Genetic risk factors for CCA

OGG1

8-oxoguanine DNA glycosylase 1

DNA repair

not significant^a

Zeng 2013 [30]

OGG1

8-oxoguanine DNA glycosylase 1

DNA repair

not significant^a

Songserm 2014 [26]

PARP-1

poly-ADP-ribose polymerase 1

DNA repair

not significant^a

Zeng 2013 [30]

XRCC1

X-ray repair cross-compelementing protein 1

DNA repair

not significant^a

Songserm 2014 [26]

XRCC1

X-ray repair cross-complementing protein 1

DNA repair

not significant^a

Zeng 2013 [30]

IL-6R

interleukin 6 receptor

inflammation

increased C allele frequency decreased risk

Prayong 2014 [34]

CHST4

sulfotransferase

metabolism

upregulated in Thai CCA

Jinawath 2006 [31]

CYP1A2

cytochrome P450 oxidase

metabolism

CYP1A2*1A/*1A decreased risk in men^a

Prawan 2005 [29]

CYP2A6

cytochrome P450 oxidase

metabolism

increased expression in CCA

Yongvanit 2012 [32]

CYP2E1

cytochrome P450 oxidase

metabolism

decreased expression in CCA

Yongvanit 2012 [32]

GST01

glutathione-s-transferase

metabolism

GST01*D140 increased risk

Marahatta 2006 [55]

GST02

glutathione-s-transferase

metabolism

not significant

Marahatta 2006 [55]

GSTM1

glutathione-S-transferase

metabolism

not significant^a

Honjo 2005 [23]

GSTT1

glutathione-S-transferase

metabolism

not significant^a

Honjo 2005 [23]

MTHFR

methylenetetrahydrofolate reductase

metabolism

A1298C CC variant increased risk^a

Songserm 2011 [27]

MTHFR

methylenetetrahydrofolate reductase

metabolism

A1298C CC variant increased risk^a

Songserm 2012 [24]

NAT1

catalyze N and O acetylation

metabolism

NAT1*11 decreased risk

Prawan 2005 [29]

NAT2

catalyze N and O acetylation

metabolism

NAT2*13, *6B, and *7A decreased risk

Prawan 2005 [29]

SULT1C1

sulfotransferase

metabolism

upregulated in Thai CCA

Jinawath 2006 [31]

UGT1A10

UDP-glucuronosyltransferase

metabolism

upregulated in Thai CCA

Jinawath 2006 [31]

UGT2B11

UDP-glucuronosyltransferase

metabolism

upregulated in Thai CCA

Jinawath 2006 [31]