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Table 1 Patients’ distribution based on treatment options along with adverse drug reactions

From: Using focused pharmacovigilance for ensuring patient safety against antileishmanial drugs in Bangladesh’s National Kala-azar Elimination Programme

 

L-AMB (ADR: n; percentage)

MILTE (ADR: n; percentage)

PARO (ADR: n; percentage)

L-AMB & MILTE (ADR: n; percentage)

L-AMB & PARO (ADR: n; percentage)

MILTE &PARO (ADR: n; percentage)

Total (ADR: n; percentage)

NKA

585 (179; 31%)

12 (2; 2/17)

0 (0; 0)

1 (0; 0)

9 (0; 0)

1 (0; 0)

608 (181; 30%)

PKDL

155 (41; 26%)

181 (29; 16%)

0 (0; 0)

15 (3; 3/15)

0 (0; 0)

0 (0; 0)

351 (73; 21%)

RELAPSE VL

64 (17; 27%)

0 (0; 0)

1 (0; 0)

7 (0; 0)

21 (0; 0)

0 (0; 0)

93 (17; 18%)

KATF

3 (2; 2/3)

0 (0; 0)

0 (0; 0)

1 (0; 0)

0 (0; 0)

0 (0; 0)

4 (2; 2/4)

RELAPSE AND PKDL

5 (2; 2/5)

0 (0; 0)

0 (0; 0)

0 (0; 0)

0 (0; 0)

0 (0; 0)

5 (2; 2/5)

CL

2 (1; 1/2)

0 (0; 0)

0 (0; 0)

0 (0; 0)

0 (0; 0)

0 (0; 0)

2 (1; 1/2)

NKA WITH PKDL

3 (0; 0)

0 (0; 0)

0 (0; 0)

0 (0; 0)

0 (0; 0)

0 (0; 0)

3 (0; 0)

Total (ADR: n; percentage)

817 (242; 30%)

193 (31; 16%)

1 (0; 0)

24 (3; 13%)

30 (0; 0)

1 (0; 0)

1066 (276; 26%)a

  1. Note:
  2. ADR adverse drug reactions, CL cutaneous leishmaniasis, KATF Kala-azar treatment failure, L-AMB liposomal amphotericin B, MILTE miltefosine, NKA New Kala-azar, PARO paromomycin, PKDL Post Kala-azar dermal leishmaniasis, VL visceral leishmaniasis
  3. aWhere the percentage value has been calculated from the total number of ADRs, irrespective of disease type and treatment method