Table 4 Baseline characteristics and parasitological responses in dihydroartemisinin-piperaquine-treated children who participated in evaluation of the comparison of estimates of parasite clearance time derived from linear regression equation and microscopy-determined parasite clearance time
Variables | Initial phase (n = 166) | Later phase (n = 155) | All (n = 321) | P value |
|---|---|---|---|---|
Male: Female | 90:76 | 93:62 | 183:138 | 0.35 |
Age (month) | ||||
 Mean (95% CI) | 37.6 (34.9–40.2) | 39.5 (36.9–42) | 38.1 (36.4–39.7) | 0.31 |
 No. ≤ 12 months (%) | 16 (9.6) | 13 (8.4) | 29 (9) | 0.84 |
Duration of illness (day) | ||||
 Mean (95% CI) | 3.8 (3.2–4.4) | 4.1 (3.4–4.7) | 3.8 (3.4–4.2) | 0.53 |
Weight (kg) | ||||
 Mean (95% CI) | 12.8 (12.2–13.5) | 13.1 (12.5–13.7) | 12.9 (12.4–13.3) | 0.56 |
Temperature (°C) | ||||
 Mean (95% CI) | 37.8 (37.6–38) | 37.8 (37.5–38) | 37.8 (37.7–37.9) | 0.8 |
No. with | ||||
  ≥ 37.5 °C (%) | 94 (56.6) | 99 (63.9) | 193 (60.1) | 0.23 |
  ≥ 40 °C (%) | 15 (9) | 13 (8.4) | 28 (8.7) | 0.99 |
Haematocrit (%) | ||||
 Mean (95% CI) | 30.6 (29.7–31.5) | 31.3 (30.6–32) | 30.8 (30.3–31.4) | 0.21 |
 No with anaemia (%) | 59 (35.5) | 45 (29) | 104 (32.4) | 0.34 |
  Mild (%) | 48 (28.9) | 43 (27.7) | 91 (28.3) | 0.65 |
  Moderate (%) | 11 (6.6) | 2 (1.3) | 13 (4) | 0.02 |
  Severe (%) | 0 (0) | 0 (0) | 0 (0) | – |
Parasitaemia (/μl) | ||||
 Geometric mean (Range) | 16 319 (2000–200 000) | 14 057 (2003–198 000) | 15 185 (2000–200 000) | 0.27 |
 Gametocytaemia (%) | 15 (9) | 4 (2.6) | 19 (5.9) | 0.02 |
Parasite positivity | ||||
 On day 1 | 87 | 83 | 170 | 0.93 |
 On day 2 | 29 | 31 | 60 | 0.66 |
 On day 3 | 5 | 2 | 7 | 0.45 |
Parasite clearance time (day) | ||||
 Mean (95% CI) | 1.8 (1.6–1.9) | 1.8 (1.7–1.9) | 1.8 (1.7–1.9) | 0.88 |
PRRD1 | ||||
 Geometric mean (95% CI) | 923 (585–1456) | 695 (421–1149) | 805 (574–1129) | 0.46 |
PRRD2 | ||||
 Geometric mean (95% CI) | 7428 (5298–10 415) | 5143 (3407–7765) | 6220 (4772–8108) | 0.3 |