Table 1 Tabular results: pooled acute phase (ACD)
From: Molecular diagnosis of Chagas disease: a systematic review and meta-analysis
Acute phase | Summary sensitivity | Summary specificity | Summary DOR (Random effects model) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Study | Sen | 95% CI | TP/(TP + FN) | TN/(TN + FP) | Spe | 95% CI | TP/(TP + FN) | TN/(TN + FP) | DOR | 95% CI | % Weight |
Benatar, 2021 | 0.769 | 0.462–0.950 | 10/13 | 217/235 | 0.923 | 0.882–0.954 | 10/13 | 217/235 | 40.185 | 10.141–159.230 | 5.90 |
Besuschio, 2017 (a) | 1.000 | 0.631–1.000 | 8/8 | 10/10 | 1.000 | 0.692–1.000 | 8/8 | 10/10 | 357.000 | 6.391–19,943.000 | 2.59 |
Besuschio, 2020 | 1.000 | 0.753–1.000 | 13/13 | 17/17 | 1.000 | 0.805–1.000 | 13/13 | 17/17 | 945.000 | 17.592–50,761.900 | 2.62 |
Bisio, 2021 (a) | 1.000 | 0.753–1.000 | 13/13 | 89/89 | 1.000 | 0.959–1.000 | 13/13 | 89/89 | 4833.000 | 91.995–253,904.400 | 2.64 |
Bisio, 2021 (b) | 0.692 | 0.386–0.909 | 9/13 | 89/89 | 1.000 | 0.959–1.000 | 9/13 | 89/89 | 377.890 | 18.865–7569.800 | 3.61 |
Cura, 2017 (a) | 0.765 | 0.501–0.932 | 13/17 | 26/30 | 0.867 | 0.693–0.962 | 13/17 | 26/30 | 21.125 | 4.540–98.296 | 5.66 |
Cura, 2017 (b) | 0.765 | 0.501–0.932 | 13/17 | 23/30 | 0.767 | 0.577–0.901 | 13/17 | 23/30 | 10.679 | 2.622–43.484 | 5.86 |
Cura, 2017 (c) | 0.706 | 0.440–0.897 | 12/17 | 30/30 | 1.000 | 0.884–1.000 | 12/17 | 30/30 | 138.640 | 7.120–2699.500 | 3.64 |
Cura, 2017 (d) | 0.765 | 0.501–0.932 | 13/17 | 29/30 | 0.967 | 0.828–0.999 | 13/17 | 29/30 | 94.250 | 9.574–927.810 | 4.54 |
Deborggraeve, 2009 (a) | 0.667 | 0.223–0.957 | 4/6 | 108/108 | 1.000 | 0.966–1.000 | 4/6 | 108/108 | 390.600 | 16.253–9387.100 | 3.40 |
Diez, 2008 | 1.000 | 0.478–1.000 | 5/5 | 12/12 | 1.000 | 0.735–1.000 | 5/5 | 12/12 | 275.000 | 4.809–15724.400 | 2.57 |
Ferrer, 2013 (a) | 0.769 | 0.607–0.889 | 30/39 | 30/30 | 1.000 | 0.884–1.000 | 30/39 | 30/30 | 195.840 | 10.908–3516.000 | 3.74 |
Ferrer, 2013 (b) | 0.795 | 0.635–0.907 | 31/39 | 30/30 | 1.000 | 0.884–1.000 | 31/39 | 30/30 | 226.060 | 12.497–4089.200 | 3.73 |
Flores-Chavez, 2021 (a) | 0.974 | 0.865–0.999 | 38/39 | 45/48 | 0.938 | 0.828–0.987 | 38/39 | 45/48 | 570.000 | 56.919–5708.100 | 4.52 |
Hernández, 2016 (a) | 0.845 | 0.740–0.920 | 60/71 | 15/15 | 1.000 | 0.782–1.000 | 60/71 | 15/15 | 163.090 | 9.101–2922.400 | 3.74 |
Hernández, 2016 (b) | 0.958 | 0.881–0.991 | 68/71 | 15/15 | 1.000 | 0.782–1.000 | 68/71 | 15/15 | 606.710 | 29.785–12,358.500 | 3.59 |
Messenger, 2017 | 0.760 | 0.549–0.906 | 19/25 | 257/257 | 1.000 | 0.986–1.000 | 19/25 | 257/257 | 1545.000 | 83.908–28448.000 | 3.71 |
Mora, 2005 | 0.348 | 0.164–0.573 | 8/23 | 142/146 | 0.973 | 0.931–0.992 | 8/23 | 142/146 | 18.933 | 5.094–70.374 | 5.99 |
Ramírez, 2015 (a) | 1.000 | 0.715–1.000 | 11/11 | 50/50 | 1.000 | 0.929–1.000 | 11/11 | 50/50 | 2323.000 | 43.759–123,317.900 | 2.63 |
Ramírez, 2015 (b) | 1.000 | 0.715–1.000 | 11/11 | 50/50 | 1.000 | 0.929–1.000 | 11/11 | 50/50 | 2323.000 | 43.759–123,317.900 | 2.63 |
Schijman, 2003 | 0.738 | 0.609–0.842 | 45/61 | 63/63 | 1.000 | 0.943–1.000 | 45/61 | 63/63 | 350.210 | 20.479–5989.000 | 3.80 |
Simón, 2019 | 0.909 | 0.587–0.998 | 10/11 | 177/177 | 1.000 | 0.979–1.000 | 10/11 | 177/177 | 2485.000 | 95.339–64,771.300 | 3.31 |
Velázquez, 2014 | 1.000 | 0.914–1.000 | 41/41 | 296/296 | 1.000 | 0.988–1.000 | 41/41 | 296/296 | 49,219.000 | 963.580–2514065.000 | 2.66 |
Viettri, 2022 (a) | 0.971 | 0.851–0.999 | 34/35 | 61/61 | 1.000 | 0.941–1.000 | 34/35 | 61/61 | 2829.000 | 112.170–71348.700 | 3.35 |
Viettri, 2022 (b) | 0.943 | 0.808–0.993 | 33/35 | 61/61 | 1.000 | 0.941–1.000 | 33/35 | 61/61 | 1648.200 | 76.864–35,342.500 | 3.53 |
Wehrendt, 2021 (a) | 1.000 | 0.692–1.000 | 10/10 | 15/15 | 1.000 | 0.782–1.000 | 10/10 | 15/15 | 651.000 | 11.954–35,452.900 | 2.61 |
Wehrendt, 2021 (b) | 0.800 | 0.444–0.975 | 8/10 | 15/15 | 1.000 | 0.782–1.000 | 8/10 | 15/15 | 105,400 | 4.519–2458.400 | 3.43 |
Pooled | 0.849 | 0.820–0.876 | 0.982 | 0.975–0.987 | 276.190 | 122.640–621.990 | |||||
No. studies | 27 | 27 | 27 | ||||||||
Heterogeneity (Chi-squared) | 108.81 (df = 26) | 117.79 (df = 26) | 63.60 (df = 26) | ||||||||
P-value | 0.000 | 0.000 | 0.000 | ||||||||
Inconsistency (I-square) | 76.1% | 77.9% | 59.1% | ||||||||
Estimate of between-study variance (Tau-squared) | 2.4158 | ||||||||||