Reduced efficacy of single-dose albendazole against Ascaris lumbricoides, and Trichuris trichiura, and high reinfection rate after cure among school children in southern Ethiopia: a prospective cohort study

Table 4 Predictors of cure rate at week 4 of single dose albendazole mass drug administration

Variables	Hookworm			Ascaris lumbricoides					Trichuris trichiura
Variables	Cured n (%)	cOR (95% CI)	P	Cured n (%)	cOR (95% CI)	P	aOR (95% CI)	P	Cured n (%)	cOR (95% CI)	P	aOR (95% CI)	P
Age group
≤ 9 years	33 (100)	Omitted		145 (64.4)	1	0.006	1	0.006	50 (46.7)	1	0.52
≥ 10 years	73 (96.1)	Omitted		437 (74.2)	1.59 (1.14–2.21)	0.006	1.6 (1.14–2.22)	0.006	175 (50.3)	1.15 (0.75–1.78)	0.52
Sex
Male	61 (96.8)	1.5(0.13–16.78)	0.75	287 (71.2)	1	0.86			104 (47.5)	1	0.42
Female	45 (97.8)	1	0.75	295 (71.8)	1.03 (0.76–1.39)	0.86			121 (51.3)	1.16 (0.81–1.68)	0.42
Co-infection with Schistosoma mansoni
No co-infection	67 (95.7)	Omitted		408 (70.8)	1	0.51			142 (49.3)	1	0.94
With co-infection	38 (100)	Omitted		174 (73.1)	1.12 (0.8–1.57)	0.51			83 (49.7)	1.02 (0.7–1.5)	0.94
Number of STH infections at baseline
Single infection	32 (94.1)	Omitted		317 (69.5)	0.6 (0.24–1.5)	0.27			69 (54.3)	2.3 (0.97–5.24)	0.06	2.3 (0.98–5.31)	0.06
Double infection	45 (100)			242 (73.6)	0.73 (0.3–1.84)	0.50			146 (48.8)	1.81 (0.82–4.03)	0.14	1.81(0.81–4.02)	0.15
Triple infection	29 (96.7)			23 (79.3)	1				10 (34.5)	1
Co-infection with other STH parasites
Yes	85 (98.8)	0.12(0.01–1.42)	0.09	344 (73.7)	1	0.11	1	0.10	186 (49.6)	1	0.89
No	21 (91.3)	1	0.09	238 (68.6)	0.78 (0.58–1.06)	0.11	0.77(0.57–1.05)	0.10	39 (48.8)	0.97 (0.6–1.6)	0.89
Pre-treatment infection intensity
Light	106 (97.2)			404 (73.5)	1.14 (0.46–2.80)	0.78			221 (50.1)	2.5 (0.78–8.13)	0.12	2.27 (0.8–8.4)	0.12
Moderate				161 (67.1)	0.84 (0.33–2.11)	0.71			4 (28.6)	1		1
Heavy				17 (70.8)	1

n: Total number of participants within each category; 1: reference category; aOR: Adjusted odds ratio; cOR: Crude odds ratio, CI Confidence interval STHs: Soil transmitted helminths. Predictor variables with P ≤ 0.2 in the univariate analyses were entered into the multivariate analysis

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